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THoR Aims to Help Future Patients “Weather the Storm” of Infection

THoR Aims to Help Future Patients “Weather the Storm” of Infection
In every population that encounters an infectious organism, a few individuals prove to be resilient—unfazed by that pathogen because they are either resistant to it (their immune systems keep the pathogen from multiplying to dangerous levels) or tolerant (they don’t get as sick as they otherwise might despite carrying high pathogen loads). Conventional disease treatments such as antibiotics have almost exclusively sought to emulate natural resistance by keeping patients’ pathogen levels as low as possible. This approach has been incredibly successful but has an increasingly serious downside: Any pathogens that survive a particular treatment can defy it from then on, giving rise to new antibiotic-resistant strains. The rising prevalence of multi-drug-resistant pathogens, as well as emerging biological threats, makes developing new medical countermeasures a national security priority.  Article 
DARPA’s new Technologies for Host Resilience (THoR) program aims to tackle the rising prevalence of multi-drug-resistant pathogens, as well as emerging biological threats. Instead of focusing on how to kill specific pathogens, THoR seeks to catalyze the development of breakthrough interventions that would increase a patient’s ability to tolerate a broad range of pathogens. The program will explore the fundamental biology of host tolerance to infection with the goal of expanding treatment options for humans in the future.
SoSITE 144

Operating in Contested Environments

DARPA’s System of Systems (SoS) Integration Technology and Experimentation (SoSITE) program aims to develop and demonstrate concepts for maintaining air superiority through novel SoS architectures—combinations of aircraft, weapons, sensors and mission systems—that distribute air warfare capabilities across a large number of interoperable manned and unmanned platforms. The vision is to integrate new technologies and airborne systems with existing systems faster and at lower cost than near-peer adversaries can counter them. 

For decades, the United States has successfully countered the threats of competitor nations by harnessing advanced technologies to create exceedingly robust and capable military platforms. But as advanced technologies have become more readily available to adversaries on commercial markets, the Nation’s focus on ever more complex weapons systems has become not just a strength but also a weakness. Effective as they are, U.S. military systems today are often too expensive to procure in the quantities needed, and may take so long to develop that the electronic components they contain are obsolete by the time they become operational. Article

DARPA Framework

DARPA Shares Its Vision for the Future

DARPA Framework 

DARPA today released Breakthrough Technologies for National Security, a biennial report summarizing the Agency’s historical mission, current and evolving focus areas and recent transitions of DARPA-developed technologies to the military Services and other sectors. The report’s release coincided with testimony by DARPA Director Arati Prabhakar before the Emerging Threats and Capabilities Subcommittee of the House Armed Services Committee, at a hearing entitled “Department of Defense Fiscal Year 2016 Science and Technology Programs: Laying the Groundwork to Maintain Technological Superiority.” The full report is available at http://go.usa.gov/3rut4. Article 

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Wanted: Technologies to Enable Automated Lookouts for Unmanned Surface Vessels

DARPA’s Anti-Submarine Warfare (ASW) Continuous Trail Unmanned Vessel (ACTUV) seeks to develop an independently deployed unmanned surface vessel that would operate under sparse remote supervisory control and safely follow the maritime “rules of the road” for collision avoidance known as COLREGS. The hull for the ACTUV prototype is under construction in preparation for planned water-borne testing of the full prototype later this year. 

DARPA’s Anti-Submarine Warfare (ASW) Continuous Trail Unmanned Vessel (ACTUV) program seeks to develop a new type of unmanned surface vessel that could independently track adversaries’ ultra-quiet diesel-electric submarines over thousands of miles. One of the challenges that the ACTUV program is addressing is development of autonomous behaviors for complying with the International Regulations for Preventing Collisions at Sea, known as COLREGS. Substantial progress has been made in developing and implementing those behaviors. Currently, ACTUV’s system for sensing other vessels is based on radar, which provides a “90 percent solution” for detecting other ships. However, radar is less suitable for classification of the type of other vessels, for example determining whether the vessel is a powered vessel or a sailboat. Additionally, one of the requirements of COLREGS is to maintain “a proper lookout by sight and hearing.” Article

Tern 144

Tern Continues Progress toward Enabling Small Ships to Host Their Own Unmanned Air Systems

Tern, a joint program between DARPA and the U.S. Navy’s Office of Naval Research (ONR), seeks to enable forward-deployed small ships to serve as mobile launch and recovery sites for medium-altitude, long-endurance unmanned aerial systems (UAS). In an important step toward that goal, DARPA has awarded prime contracts for Phase 2 of Tern to two companies: AeroVironment, Inc. and Northrop Grumman Corp. 

DARPA has awarded prime contracts for Phase 2 of Tern, a joint program between DARPA and the U.S. Navy’s Office of Naval Research (ONR). The goal of Tern is to give forward-deployed small ships the ability to serve as mobile launch and recovery sites for medium-altitude, long-endurance unmanned aerial systems (UAS). These systems could provide long-range intelligence, surveillance and reconnaissance (ISR) and other capabilities over greater distances and time periods than is possible with current assets, including manned and unmanned helicopters. Further, a capacity to launch and retrieve aircraft on small ships would reduce the need for ground-based airstrips, which require significant dedicated infrastructure and resources. The two prime contractors selected by DARPA are AeroVironment, Inc., and Northrop Grumman Corp. Article

RFI 144

Petaflops On Desktops: Ideas Wanted For Processing Paradigms That Accelerate Computer Simulations

DARPA’s ACCESS RFI seeks new processing paradigms that have the potential to overcome current barriers in computing performance. Old fashioned analog approaches may be part of the solution. 

Whether designed to predict the spread of an epidemic, understand the potential impacts of climate change, or model the acoustical signature of a newly designed ship hull, computer simulations are an essential tool of scientific discovery. By using mathematical models that capture the complex physical phenomena of the real world, scientists and engineers can validate theories and explore system dynamics that are too costly to test experimentally and too complicated to analyze theoretically. Over the past half century, as supercomputers got faster and more powerful, such simulations became ever more accurate and useful. But in recent years even the best computer architectures haven’t been able to keep up with demand for the kind of simulation processing power needed to handle exceedingly complex design optimization and related problems.  Article

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